The AGI Dermatics lead compound is T4N5 Liposome Lotion, known as Dimericine, which encapsulates the DNA repair enzyme T4 endonuclease V in a liposome engineered to deliver the enzyme into cells of the skin. Studies in cell cultures and animals specify T4N5 liposomes increased repair of DNA damage caused by UV. In clinical testing in xeroderma pigmentosum (XP), a genetic disease predisposing to skin cancer, Dimericine reduced the incidence of pre-malignant actinic keratosis and basal cell car...
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