EvaMist is the wonder preparation designed and developed for use in the treatment for the Vasomotor Symptoms associated with the Menopausal disorders. EvaMist is produced by the pharmaceutical company that is greatly devoted to the development and commercialization of the wonder therapeutic products assigned for the obesity as well as sexual health, known as Vivus Inc. The drug is formulated by using Estradiol is its key ingredient. Vivus has declared the positive results from its essential Phase 3 clinical trials of EvaMist. The studies have exhibited the statistically important decrease in the number and severity of reasonable and sever hot flashes for all the three doses that were tested.

EvaMist is the wonder, once dose per day, proprietary, first of its category, transdermal spray that delivers Estradiol which is the naturally occurring estrogen, for the treatment of hot flashes in women. EvaMist is the small convenient hand held and easy to use sprays which is designed to provide the comfortable means of delivering the preset dosage of Estradiol through the skin. EvaMist is the quick drying, non-irritating and invisible after application on the skin. EvaMist formulation after once applied on the skin is not affected by washing as well as does not transfer to the other person touching that area of the skin as proved by the studies. EvaMist is easily applied as one; two or three sprays as required or recommended by the physician. 

The Phase 3 studies by Vivus evaluated the safety and efficacy of EvaMist for the treatment of the hot flashes in women facing menopausal disorders. This Phase 3 trials which were carried out at 43 different places in the United States, was the 12 week, randomized, double blinded placebo controlled study on 454 menopausal women. The study was conducted under the Special Protocol Assessment-SPA from the US – FDA.