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Fluticasone furoate (685698) is a novel, enhanced affinity steroid being developed by GlaxoSmithKline (GSK) for use in the treatment of allergic rhinitis as an intranasal spray. The drug fluticasone furoate is an enhanced affinity intranasal corticosteroid with the proposed name of AllermistTM in the US and Avamys(R) in Europe. The efficacy and safety of fluticasone furoate have been evaluated in seven clinical trials with 2,555 adult and pediatric patients two years of age and older with symptoms of SAR and PAR. Patients taking this medicine reported significant improvements in a range of nasal symptoms compared to those taking a placebo. In adult patients with SAR, in addition to nasal symptom improvement, fluticasone furoate use was also consistently associated with significant improvement in ocular symptoms such as watery and itchy eyes.
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Developed after ergonomic testing, fluticasone furoate is dispensed using a novel nasal device, designed with the patient in mind. There is minimal or no aftertaste with fluticasone furoate and the product is unscented and alcohol-free.
Allergic rhinitis is an inflammatory disease characterized by the symptoms of runny nose, nasal congestion, watery eyes, sneezing and itching of the nose and ocular symptoms of red, itching/burning and watery eyes. Symptoms do occur after exposure to allergens such as mold spores and pollens, which cause SAR, or to year-round allergens such as dust mites or animal dander, which cause PAR.
One of the most prevalent and chronic diseases in the U.S., allergic rhinitis affects up to 40 million people annually, including 10 to 30% of adults and up to 40% of children. In Europe, more than 1 in every 5 adults are estimated to suffer from allergic rhinitis, of which nearly half are undiagnosed.
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