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Orlistat a.k.a. Xenical, promotes weight loss by preventing the fat in foods from being digested and absorbed. The fat in food is broken down in the intestine by an enzyme called lipase, so that it can be absorbed into the body. Orlistat blocks the effects of lipase, thus preventing the breakup and absorption of fat. Studies show that up to 25% of potential fat absorption is blocked by Orlistat. The unabsorbed fat will be excreted in the stool.
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Orlistat is used in combination with a reduced–calorie diet, thus promoting weight loss. After the required weight has been lost, to prevent putting the weight back on, Orlistat can be used. Most of the persons who use Orlistat are obese, and have a body mass index of over 30 kg/m2. Studies show that when the drug is taken for six months to a year average weight loss was approximately 12 to 13 pounds.
Orlistat is a prescription drug and the recommended dosage is one capsule of 20 mg three times daily. It is taken during or one hour after a meal that contains about 15 mg of fat.
Orlistat is not recommended for pregnant women and nursing mothers.
Side effects include oily spotting on underwear, urgent bowel movements, fatty or oily stools, increased bowel movements, abdominal pain, and incontinence (inability to control stool). Less than one percent of patients say they experienced a number of these symptoms within the first year. Normally side effects are seen within three months and in some cases it’s as early as one week.
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