While recognized as the most powerful antidepressant, Silenor – Doxepin is also known of exhibiting various unwanted side effects such as: dry mouth, dry eyes besides other anti-cholinergic effects, but by using the lower dosage during the clinical trials of Silenor by Somaxon Pharmaceuticals, any such side effects were not noticed. Silenor does not work through the set of brain receptors called the benzodiazepine or GABA receptors like most of the other recognized insomnia medications. Loss of memory, vision, dependency and obsession are associated with the drugs that effect on such receptors. 

While the technique of functionality in promoting sleep effects by Silenor is not perfectly known as yet, the medication defers from the generally available sleep promoting preparations of which the effects are routed via histaminergic systems. Doxepin, the key ingredient of Silenor is proven extremely powerful histamine-H1 antagonists which are the established factors of minimizing restlessness and are believed of promoting the instigation as well as maintain the sleep process.