Treatment with Velac was found to be more effective than tretinoin alone in inflamed lesions and at least similar in open and closed comedones. In two of the three studies on the whole acne severity grade was significantly more reduced when compared with tretinoin. Velac is also more effective than clindamycin alone in the treatment of non-inflamed lesions. In the two multicentre studies the reduction of the on the whole acne severity grade was also more favourable for the new gel formulation. A more rapid response occurred with Velac than with either component used alone.

This study was designed to assess whether the recently developed fixed formulation of 1.2% clindamycin phosphate and 0.025% tretinoin in a gel base (Velac), further referred to as Clindamycin phosphate Tretinoin Gel is at least as effective as a proprietary 0.025% tretinoin gel formulation showing an additional anti-inflammatory effect in the treatment of moderate to severe acne vulgaris.